伝染性単核症患者の総血中乳酸脱水素酵素活性とアイソザイム

Total Lactate Dehydrogenase and Its Isoenzymes in Serum of Patients with Infectious Mononucleosis

　従来，血中乳酸脱水素酵素（LD）活性の増加は，過反応性B細胞リンパ腫および伝染性単核症に特徴づけられる疾患において報告されてきた．しかしながら，伝染性単核症でのLD活性の上昇の原因と重要性は完全に明らかになったわけではないし，伝染性単核症患者の血中LDアイソザイムのパターンの特徴を明らかにしようとする研究が少数あるのみである．また，文献からではLDが果たして伝染性単核症の診断の良い検査となりうるかどうかは不明である．

　われわれは伝染性単核症患者の血中の総LD活性を測定し，そしてこれらの患者のLDアイソザイムパターンの特徴を究明するために，血中LD各アイソザイムの比率を測定することにした．さらに，血中LD活性が伝染性単核症の診断に役立つか否かを見るために，これらの所見とASTおよびALT活性との相関関係をも見ようとした．総LD活性，LDアイソザイム，AST，ALTを82人の伝染性単核症患者で次々に測定した．

　Increased lactate dehydrogenase (LD, EC 1.1.1.27) activity in serum has been reported in disorders characterized by hyperactive B cell proliferation, especially B cell lymphomas and infectious mononucleosis (IM). However, the cause and significance of the increased LD activity in IM are not entirely clear, and only a few studies have tried to characterize the pattern of LD isoenzymes in serum of patients with IM. It is also unclear from the literature whether LD may serve as a good test for the diagnosis of IM.

　We decided to determine total LD activity and the proportions ofthe LD isoenzymes in sera of patients with IM, to characterize thepatterns of the LD isoenzymes in these patients. We also wanted tocorrelate these findings with the activities of aspartate aminotransferase (AST, EC 2.6.1.1) and alanine aminotransferase (ALT, EC 2.6.1.2)in serum in these patients and to find whether LD activity in serummight be useful in diagnosing IM. Total LD, LD isoenzymes, AST, andALT were determined in 82 consecutive patients with IM.