頭頸部における重複癌4症例—長期のtime lagをもった2症例を中心として

Multiple Primary Malignant Neoplasms of the Head and Neck: Report of 4 Cases

　I．はじめに

　重複癌の症例は，近年癌症例数の増加につれて報告例も増加している。なかでも発生間隔に差のある，いわゆる異時重複癌の症例が増加しており，発生間隔が10年を越えるものもかなりみられるようになってきている。筆者らは，最近つづけて4例の頭頸部の重複癌症例を経験したので若干の考察を加えて報告する。

　Progressive increase in the population in the cancer age group may result in an increase of the incidence of multiple primary malignant neoplasms.

　The first case, a 11-year-old boy, showed bilateral retinoblastoma in four months after birth, and he developed hemangiopericytoma in the ethmoid sinus as the second neoplasm in spite of being well from the primary lesion. No such a case had been reported until present. The second case, a 56-year-old man, who had been operated on for laryngealcancer thirteen years previously, developed malignant lymphoma as the second malignancy, but had no sign of recurrence of the initial one. The third case was a 62-year-old man, and lie had synchronously developed two primary cancers involving of the right parotid gland and the gum. The fourth case, a 76-year-old woman, developed the second primary tumor in the palate seventeen months after the surgery for thyroid cancer.

　The time lapse between the primary and secondary lesions was over ten years in case 1 and 2, and these cases were well and without recurrence from the initial malignancy. Progressive increase in the cure and survival rates resulting from the improved method of cancer detection and therapy should permit the occurrence of additional primary malignant neoplasms in the same individual.