喉頭にみられた多中心性発癌の1症例

MULTICENTRIC CARCINOMA OF THE LARYNX

　I．はじめに

　喉頭癌をふくむ重複癌は稀なものではなく，その頻度は喉頭癌全体の7％程度と考えられる^14）。今までわれわれの教室でもこのような症例の幾つかを報告してきた^{10）12）19）20）}。

　しかし，喉頭における多中心性発癌に関する文献は少ない。最近，われわれは喉頭に2つの腫瘍を認め，さらには食道癌を併発した症例を経験した。病理組織学的検討の結果，本症例の喉頭腫瘍は多中心性に発癌した扁平上皮癌であると考えられたのでその概要を報告する。

　Laryngectomy was performed on a man, aged 69, who suffered laryngeal cancer. Examination of the exterpated specimen revealed two separate sources of the origin of the cancerous tissues; one in the ventricular space and the other into the laryngeal vestibule. Microscopic examination of these specimen showed that the two growths are derived from separate origin, but both proved to be composed of squamous cell epithelium.

　Recurrence of the tumor was not seen for 4 years, thereafter, postoperatively. However, in January 1975, the patient complained of hematemesis and dysphagia. X-ray and esophagoscopic examinations showed cancer (ImEi 16cm spiral type) of the esophagus.

　With the administration of bleomycin the patient's condition showed improvement.