ACTH, Cortisoneによる顆粒細胞減少性アンギーナの1治験例

　緒言

　顆粒細胞減少症は1922年Werner Schultzが初めて報告して以来，一般に高熱，特異なる血液像，特有なる口腔並びに咽頭所見，及び時として黄疸を伴い，急激なる経過をとる重篤なる疾患とされている。その治療に関しては古くから数多くの方法が挙げられて来たが，最近Caldwell, Mc Millinの治療経験から，ACTH, Cortisoneが本症に非常に効果的である場合が認められる様になつた。

　我々は最近重篤なる顆粒細胞減少性アンギーナの患者にACTH, Cortisoneを使用して著効を納めたのでここに報告する次第である。

Nishihata and associates report a case of agranulocytosis in whom the condition is be-lieved to be the result of drug sensitivity from previous use of sulfa-drugs and antibiotics. The recovery of the case was effected by use of ACTH (total amount 360 mg) and cortisone (total amount 300 mg) for the period of 6 days. A woman, aged 40, complaining of sore throat and high fever which ran between 33 and 40 degrees is hospitalized. Blood examination showed the whife count to he only 1,200 with a marked decrease of neutrophils while the lymphocyts were on the side of relative incre-ase. The recovery after the treatment was remarkable in that on the 12th the leucocytic count was increased to 6,500 and the general blood picture returning to normal with a complete relief of the patient from her clini-cal symptoms.