化学療法にて難治なりしルドイヒのアンギーナの1例

　緒言

　本疾患は1838年Wilhelm Friedlich v. Ludwig氏により，頣部蜂窠織硬結症として報告されてから，今日まで，その病因はもとより，症候，治療に関して数多くの報告が提出されている。第二次大戦後，抗生物質の登場に伴つて，これが本症の治療に供されること多く，治療法に相当の改革を齎らしたとは言え，今日では，これら抗生物質の普及と濫用の結果，耐性菌出現の問題，真菌症の問題等が漸く注目をあびるに至つている。

　吾々は極く最近，ナルフア剤とペニシリンの併用が全く効を奏せず，顎下部外切開を施したる後に，テトラシン，オーレオマイシンの強力なる化学療法を施して，漸く治癒せしめえた重篤なるルドイヒのアンギーナの1例を経験したので此処に報告し，諸賢の御批判を乞う次第である。

　Kawashima and associates report a case of Ludwig's angina that failed to respond with a cure to use of antibiotics. Since the end of the war there have been many reports concerning this disease that have been cured by use of chemotherapy without necessarily resorting to surgical means in the treatment. However, in the present case a blind usage of antibiotics proved to be without effect with the treatment being finally reduced to surgical measures and establishment of the type of organism that caused offence and selection of antibiotics according to susceptibility of those particular offender. By using in this way a selected antibiotics in large amount the case was finally brought to cure. The authors maintain that though effectivity of antibiotics in infections can not be denied yet, surgical means in establishing a correct diagnosis can not likewise be ignored in light of recent advances made in the former therapeutic agent.