前庭半規管の刺戟又は麻痺症状に対するトラベルミン（Travelmin）の使用経験

　迷路性の眩暈や，動揺病（motion sickness）の予防及び治療には，古来多くの薬物が試みられ現在吾が国では，大阪市立医大長谷川教授発案の重曹注射，米国では，ドラマミン^1）2）（Dramamine）等が盛んに用いられている。吾々は，最近，同樣の目的のために製造せられたトラベルミン（Travelmin）日本術材製品につきその作用を，健康人，動物，及び臨牀例において検討する機会があつた。

　トラベルミン錠の化学的組成はBenadrylhydrochlorideと，8-Cheortheophyllineの混合物であつて，その混合比は（質量で）30対25である。Benadrylhydrochlorideの融点は160℃8-Chlortheophyllineのそれは300℃で前者は水に溶解するが後者は不容である。（尚注射は水に易溶性で中性なるDihydroxypropyltheophyllinを以つて8-chlortheophyllinにかえてある）

　WATANABE and associates investigate the actions of 'Travelmine', the tablet form of which embodying Benardryl-Hydrochloride and 8-Chlorotheophyllin and, soluble form for injections, Benardrylhydrochloride and Hydroxypropyltheophyllin, on the vestibule and semicircular canals. Their conclusions are as follows: (1) The use of the agent when the ear was weakly stimulated with instillation of 2 cc of water at 10 degrees centigrade definitely prolonged the latent period in which the nystagmus was manifested and lengthened the time the nystagmus maintained.

　(2) The agent was capable of allayng Joss of equilibrium which was inckccd in a rabbit by injection of 5 percent solution of cocaine hydrochloride in the middle ear cavity.

　(3)It was also competent in alleviating symptoms of vestibular vertigo which is manifested with spontaneous nystagmus but it did not act as a preventive towards recurrence of those symptoms.