チャールズ ミラー フィッシャー—偉大なる観察者

Charles Miller Fisher: The Grandmaster of Neurological Observation

チャールズ ミラー フィッシャーは脳卒中学の創始者である。臨床-病理学的観察から脳梗塞の発症機序のすべてを解明した。すなわち心房細動と塞栓症，一過性単眼盲と内頸動脈疾患，ラクナ梗塞とラクナ症候群。しかも，抗凝固，抗血小板，頸動脈内膜剝離術などの治療に結びつけた。さらに，正常圧水頭症やミラー フィッシャー症候群などGeneral Neurologyにも貢献し，晩年には人間行動の神経学への道筋をも示した。総じて彼は偉大な観察者であった。

Abstract

Charles Miller Fisher is widely regarded as the father of modern stroke neurology. He discovered almost all pathomechanisms of cerebral infarction, including embolism from atrial fibrillation, carotid artery disease, and lacunar infarcts and their syndromes, by the most meticulous clinico-pathological observations. Moreover, his work provided the basis for treatments such as anticoagulation, antiplatelet therapy, and carotid endarterectomy. He also contributed greatly to several topics of General Neurology; for example, migraine, normal pressure hydrocephalus, and Miller Fisher syndrome. In his late years, he tried to expand the neurological field to the more complex disorders of human behavior, including hysteria, dementia, and ill-defined pain syndromes. He thus became known as the grandmaster of refined neurological observation. His lifelong detailed studies were crucially important in helping neurologists all over the world recognize disorders and syndromes that had not previously been understood.