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Relationship between lamina cribrosa defect and choroidal microvasculature dropout Hideo Tate 1 , Yumiko Sudou 1 , Kenshin Sodeyama 1 , Chisato Ohtaki 1 , Akari Aoyagi 1 , Yoshiki Ueta 1 1Shinseikai Toyama Hospital Eye Center pp.1598-1605
Published Date 2022/11/15
DOI https://doi.org/10.11477/mf.1410214638

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Abstract Purpose:To investigate the relationship between lamina cribrosa defect and choroidal microvasculature dropout(Ch MVD)and the factors that cause lamina cribrosa defect.

Subjects and Methods:Thirty-three patients(37 eyes)diagnosed with normal tension glaucoma at our hospital were included in this study. The study methodology was as follows:AngioVueTM(Optovue)was used to image the 4.5×4.5 mm range in the Angio disc mode, and we extracted only those images that showed Ch MVD in either the superior or inferior intrapapillary and peripapillary areas of the choroid images. The area corresponding to the Ch MVD was imaged using enhanced depth imaging technique by SPECTRALIS® OCT(Heidelberg)in high resolution mode and 100 image addition to extract the lamina cribrosa defect. We classified the patients into two groups, with and without lamina cribrosa defect, and compared the percentage of partial defect and the background between the groups.

Results:Lamina cribrosa defects in the area corresponding to Ch MVD were found in 12 of 37 eyes(32%). In the background comparison between the groups with and without lamina cribrosa defects, significant differences were observed in refraction value:−7.31D in the group with lamina cribrosa defects and −3.55D in the group without lamina cribrosa defects(p=0.02);in axial length:27.56 mm in the group with lamina cribrosa defects and 25.30 mm in the group without lamina cribrosa defects(p=0.01);and in optic nerve ellipticity:0.75 in the group with lamina cribrosa defects and 0.84 in the group without lamina cribrosa defects(p<0.05). The majority of the lamina cribrosa defects were found in eyes with high myopia.

Conclusions:In this study, the percentage of patients with lamina cribrosa defects at the Ch MVD site was about 30%, and most of the lamina cribrosa defects were found in high-myopic eyes. The partial defects were thought to be caused by a tear in the attachment of the lamina cribrosa plate from the temporal traction of the optic disc due to ocular axis elongation.


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