脊椎手術後の疼痛に対するプレガバリンの早期投与の検討

Effect of Early Pregabalin Administration on Postoperative Pain after Spinal Surgery

　背景・目的：脊椎手術後の疼痛管理は，患者のQOLに大きく影響する．これまでのNSAIDsによる治療に加え，プレガバリンを用いることで，疼痛管理の向上を図ることが可能か検討を行った．

　対象と方法：脊椎疾患の手術を受けた患者34例をロキソプロフェン単独群(以下，単独群)とロキソプロフェンとプレガバリン併用群(以下，併用群)の2群に割り付けを行い，VAS値の変化と患者による印象について評価した．

　結果：併用群においてVAS値と患者による印象評価の高い改善効果が認められた．併用群において，めまい，眠気，ふらつき，浮腫の副作用が認められたが服薬中止に至る症例はなかった．

　まとめ：脊椎手術後の疼痛に対する早期プレガバリンの投与は有用である．

　Background ＆ Objective：Pain control after spinal surgery greatly affects patients' quality of life (QOL).　This study aimed to evaluate the improvement of pain control with loxoprofen, a conventional NSAIDs combined with pregabalin.

　Method：Thirty-four patients who had undergone surgery for a spinal disease were assigned to 2 groups, a loxoprofen monotherapy group (monotherapy group) and a loxoprofen plus pregabalin combination therapy group (combination therapy group), and changes in their VAS scores and patient impressions were evaluated.

　Outcome：The results showed higher therapeutic efficacy based on the VAS scores and patients' impressions in the combination therapy group.　Although adverse drug reactions in the form of dizziness, somnolence, lightheadedness, and edema were noted in the combination therapy group, none led to withdrawal of pregabalin.

　Conclusions：Early administration of pregabalin is a useful treatment for postoperative pain after spinal surgery.