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TREATMENT OF DEPRESSIVE STATES WITH IMINODIBENZYL DERIVATIVE (G 22355), LÉVOMÉPROMAZINE Tonao Sakurai 1 , Sukeomi Matsuo 1 1Dept. of Neuropsychiatry, Faculty of Medicine, Kyushu Univ. pp.67-78
Published Date 1960/1/1
DOI https://doi.org/10.11477/mf.1406200880

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  • Abstract
  • Look Inside

The comparative drug study in the treat-ment of depressives states with Tofranil and Lévomépromazine was conducted, which was designed to use Tofranil, Lévomépromazine, and a combination of both.

The results obtained were as follows.

The patients who showed"moderate to marked improvement"were:

(1) 11 (38%) of 29 pts. on Tofranil, (2) 19 (49%) of 39 pts. on Lévomépromazine, (3) 25 (71%) of 35 pts. on combined use of both.

In our study, it was observed that Tofra-nil seemed to be most effective against"the feeling of being ill or drop of vital power", others the effect of Lévomépromazine is striking in patients with the agitated feeling of anxiety.

Best responses were obtained in cases of endogenous depression showing the typical symptoms. In fact, 87 per cent of the pa-tients (20 out of 23 cases) put on the combi-nation of both drugs showed much improve-ment. Serious or particularly annoying si-de-effects were not observed in any case. Our findings clearly indicate that combined use of Tofranil and Lévomépromazine in the treatment of depression was very much effective.


Copyright © 1960, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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