Phenothiazine誘導体Lévomépromazineによるうつ病の治療について

TREATMENT OF DEPRESSIVE STATES WITH LÉEVOMÉPROMAZINE

　我々はうつ病34例，うつ状態2例，躁状態1例計37例にLévomépromazineを使用し，次の結果を得た。

　1．Lévomépromazineは不安，苦悶を主訴とするうつ病に特効的な作用を示すように思われた。

　2．Lévomépromazineを投与した37例中著効以上の効果を示したものは20例の54.1％で，我我の分類によると，反応性うつ病，内因性うつ病，躁状態に特に効果があつた。

　3．副作用は他のPhenothiazine誘導体の副作用と余り変りないが，全身倦怠感，口渇，鼻閉は他の薬物より強いと思われたが，いずれも危険はない。外来患者にはその事を説明して使用すれば，良い結果を得る。

　4．他の薬剤，例えばIminodibenzyl誘導体であるTofranilと併用して，更に効果が上つたことは，うつ病に占めるLévomépromazineの大きな役割を示唆しているように思われた。

Depression was the most prominent sym-ptom in 37 patients treated with Lévomé-promazine. Their diagnoses were manic depre-ssive, depressed (35), manic depressive, ma-nic (1), and dementia praecox with depressive coloring.

(1). The clinical results obtained were as follows:

Twelve patients showed complete recovery and 8 were much improved, 9 slightly impr-oved, and 8 unchanged. The drug was most effective when the depressive stated is accompanied by anxiety and psychomotor agitation. Lévoniépromazine and chlorpro-mazine were about equal in their side-effects, however, in general, Lévomépromazine appe-ared to be stronger than the latter in develo-ping fatigue, thirsty, and stuffiness. No severe reaction was noted at all. Also it showed that the benefit was available for the out patients in sufficient explanation of side-effects. Lévomépromazine in combi-nation with Iminodibenzyl derivative has produced some excellent improvement in the majority of cases. In summary, it is quite apparent that Lévomépromazine has good efficacy for the depressive state.