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我々はうつ病34例,うつ状態2例,躁状態1例計37例にLévomépromazineを使用し,次の結果を得た。
1.Lévomépromazineは不安,苦悶を主訴とするうつ病に特効的な作用を示すように思われた。
2.Lévomépromazineを投与した37例中著効以上の効果を示したものは20例の54.1%で,我我の分類によると,反応性うつ病,内因性うつ病,躁状態に特に効果があつた。
3.副作用は他のPhenothiazine誘導体の副作用と余り変りないが,全身倦怠感,口渇,鼻閉は他の薬物より強いと思われたが,いずれも危険はない。外来患者にはその事を説明して使用すれば,良い結果を得る。
4.他の薬剤,例えばIminodibenzyl誘導体であるTofranilと併用して,更に効果が上つたことは,うつ病に占めるLévomépromazineの大きな役割を示唆しているように思われた。
Depression was the most prominent sym-ptom in 37 patients treated with Lévomé-promazine. Their diagnoses were manic depre-ssive, depressed (35), manic depressive, ma-nic (1), and dementia praecox with depressive coloring.
(1). The clinical results obtained were as follows:
Twelve patients showed complete recovery and 8 were much improved, 9 slightly impr-oved, and 8 unchanged. The drug was most effective when the depressive stated is accompanied by anxiety and psychomotor agitation. Lévoniépromazine and chlorpro-mazine were about equal in their side-effects, however, in general, Lévomépromazine appe-ared to be stronger than the latter in develo-ping fatigue, thirsty, and stuffiness. No severe reaction was noted at all. Also it showed that the benefit was available for the out patients in sufficient explanation of side-effects. Lévomépromazine in combi-nation with Iminodibenzyl derivative has produced some excellent improvement in the majority of cases. In summary, it is quite apparent that Lévomépromazine has good efficacy for the depressive state.
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