散在性脳脊髄炎様症状を呈した慢性ブロバリン中毒後遺症の2例—ハイドロコーチゾン脊椎腔内注入の効果

Two Cases Presenting Symptoms like Encephalomyelitis Disseminata caused by Brovarin Intoxication: and the Effect of Hydrocortisone (Intrathecal Administration)

　ブロバリン中毒の後遺症として長期にわたり神経症状を呈することは極めて稀であるが，我々は散在性脳脊髄炎様症状を呈した2例を観察し，且つこれらの患者にハイドロ・コーチゾンを脊椎腔内に注入し，或程度の効果をおさめたのでここに報告する。

The case, a 42 years old man, used Brovarin 1-9mg/a day for 2 years 6 months.

Suddenly 39°fever and disturbance of cons-ciousness for one hour could be observed. For 2 day delirious state. After that disturbance of gait, obscure speech, disturbance of urina-tion.

After 3 months he entered our clinic. His main symptoms were bulbar symptoms, ataxie, pyramidal symptoms, disturbance of gait and slight disturbance of urination.

Those symptoms were improved momenta-rily by the hydrocortisone intrathecal adminis-tration, but returned.

The 2. case is a 51 years old man, who used Brovarin 0.5-4mg/a day, mixed with Veronal. As a slight disturbances of speech and gait appeared, he stopped the use of Brovarin. After one year those symptoms disappered.

But he used Brovarin 2-5mg/ a day again, for 10 years. The disturbances of speech and gait appeared again.

After two months he entered our clinic. His symptoms were bulbar symtoms, ataxie, incomplete pyramidal symptoms and distur-bance of gait.

Those symptoms were improved by the hydrocortisone intrathecal administration. This treatment effected especially the distur-bance of gate.