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Comorbidities in a Clinical Sample of Patients with Social Anxiety Disorder: Risk factors of subsequent mood disorders Koji TADA 1 1Jimbocho Mental Health Clinic, Tokyo, Japan Keyword: Social anxiety disorder , Comorbidity , Bipolar affective disorder , Obsessive-compulsive disorder , Atypical features pp.427-435
Published Date 2013/5/15
DOI https://doi.org/10.11477/mf.1405102445

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 The current study examined differences in gender, the age of onset of social anxiety disorder(SAD), comorbidities, family histories, and other clinical characteristics among 123 outpatients with nongeneralized and generalized SAD. The associations between these variables and comorbid major depression or bipolar affective disorder were evaluated with logistic regression analyses.

 The ages of onset of affective disorder were significantly lower in depressed patients with generalized SAD(22.6 years old)than in those with nongeneralized SAD(29.0 years old). A logistic regression analysis revealed that comorbid depression was significantly associated with the age of onset of SAD(odds ratio, 0.9).

 Nine patients developed(hypo-)manic episodes during antidepressant treatment. Changes in diagnoses of comorbid depression to bipolar disorder were significantly associated with comorbid obsessive compulsive disorder(OCD;odds ratio, 14.28), atypical features of depressive episodes(odds ratio, 16.09), and the duration of treatment(odds ratio, 1.03).

 The present results indicated that the age of onset of SAD predicted subsequent depression, and comorbid OCD and atypical features(hypersomnia, overeating)predicted a switch from comorbid depression to bipolar disorder during antidepressant treatment.


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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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