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Ventinatory response during exercise in patients with ischemic heart disease Tetsuji Kado 1 , Hideki Fujii 1 , Hiroyuki Nakata 1 , Hiroaki Miyatake 1 , Katsumi Minamiji 1 , Kazuhiro Fujitani 1 , Hisashi Fukuzaki 1 1The First Department of Internal Medicine, Kobe University School of Medicine pp.823-827
Published Date 1984/8/15
DOI https://doi.org/10.11477/mf.1404204496

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  • Abstract
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In recent years, many exercise tolerance tests have been performed in patients with ischemic heart disease (IHD), and these studies have been mainly estimated by electrocardigoraphy. However, the studies estimated the changes of respiratory re-sponses during exercise were very rare, although physiologically respiratory functions have great influences on cardiovascular system. The purpose of this study is to evaluate the relationship betweencardiovascular and respiratory responses during exercise in patients with IHD.

The mean pulmonary capillary pressure (mPCP) and ventilatory responses were measured in 15 patients (mean age 54.9 years) with angina pectoris (AP) and 15 patients (mean age 54.9 years) with old myocardial infarction (OMI) by bicycle ergometer exercise. There was no significant difference between AP and OMI in ventilatory responses.

The patients were divided into two groups on the maximum mPCP during exercise : Group A (patients whose maximum mPCP increased more than 25mmHg), Group B (patients whose maximum mPCP increased less than 25 mmHg), There was no significant difference in maximum minute volume (VE) between both groups. Respiratory rates (RR) during exercise in group A were greater than group B. The increment of tidal volume (VT) during exercise in gruop A was significantly lower than group B. There were no significant differences in Pao2, Paco2 and PH during exercise between both groups.

These results suggest that ischemia-induced left ventricular dysfunction increases left ventricular end-diastolic pressure and mPCP, which effect on the lung mechanics mainly consisted of reduced lung compliance. Therefore, in patients with 1HD whose mPCP increase more than 25mmHg, the increment in RR rather than VT mainly contributed to get adequate VE during exercise. We could evaluate the cardiovascular functions in patients with IHD by measuring the ventilatory responses during exercise.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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