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Abnormal pulmonary deposition of radioactive aerosol in patients with pulmonary emphysema Akira Shida 1 , Yoshitugu Minami 1 , Tosio Kirisawa 1 , Yoshikazu Kawakami 1 , Makoto Murao 1 , Masamiti Furudate 2 1The First Department of Internal Medicine, School of Medicine, Hokkaido University 2Department of Radiology, School of Medicine, Hokkaido University pp.817-822
Published Date 1984/8/15
DOI https://doi.org/10.11477/mf.1404204495
  • Abstract
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Aerosolized 99mTC was inhaled by patients with pulmonary emphysema to study patterns of ab-normal deposition and underlying mechanisms. Twenty-three patients with pulmonary emphysema confirmed by alveolobronchograms underwent aerosol inhalation and pulmonary function tests including airway resitance (Raw), functional residual capacity by body plethysmograph (FRC-box) and He dilution (FRCHe), pulmonary compliance, and arterial blood gases. The ab-normal depositions were classified into central and peripheral types by two observers and each pattern was divided into three grades.

Central type deposition was seen in all patients and 11 patients disclosed peripheral types deposition also. Scores of central and peripheral deposition were positively correlated to Raw. FRCbox minuts FRCHe (air trapping) and FRCbox related pos-itively to scores of central deposition. PaCO2 related positively to score of peripheral deposition. Frequency dependence of compliance did not relate to central and peripheral type depositions.

These results indicate that the main underlying mechanism for central deposition is increased airway resistance closely related to pulmonary emphysema. Airway abnormalities were thought to be an additional mechanism for combined central and peripheral depositions.


Copyright © 1984, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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