健常例および慢性肺疾患例の経時的にみた換気機能の推移

Longitudinal Study of the Ventilatory Functions in Normal and in Chronic Lung Disease

　加齢および肺疾患にともなう換気機能の成績はすでに多く報告されているが，これらの報告にはおのおのの対象について1回の検査より得られたものが多く，長期にわたり同じ対象を観察した成績は少ない。

　ここでは長期にわたり同じ対象を観察した成績にもとづいて，健常例の加齢および慢性肺疾患例の経過にともなう肺・胸郭の変化を換気機能の面から検討した。また健常例の換気機能について同じ対象の加齢にともなう変化（age change）と異なる対象の年齢別にみた変化（age difference）についても比較した。

Longitudinal study that follows the ventila-tory functions of normal and diseased subjects was presented to discuss the functional as-pects of aging and chronic lung disease.

Over an average period of 5 years obser-vations were made of 30 normal, 29 emphy-sematous and 13 fibrotic male subjects.

1) The means of the observed changes per year in the normal group were decrease of 10 ml for VC, 40 ml for FEV_1.0, 1.0% for FEV_1.0% and increase of 0.1 l/min for MVV, 0.4% for RV/TLC respectively.

Besides slightly greater decrease in FEV_1.0 and FEV_1.0%, these age changes were found to be similar to the age differences by 594 normal male individuals, ranging from 22 to 81 years of age.

2) The differences of annual ventilatory changes between the normal and the diseased group were compared.

Statistical differences (P<0.05) were found between the normal and the emphysema group for VC, IC, ERV, and between the normal and the fibrosis group for FEV_1.0%.

3) The differences of annual ventilatory changes ratios between the normal and the diseased group were compared.

Statistical differences (P<0.05) were found between the normal and the emphysema group for VC, IC, FEV_1.0, MVV, and not found between the normal and fibrosis group for any of the measurements.

4) During the period of the observation, the individual variations of the ventilatory functions were remarkable in the fibrotic subjects.