多発性骨髄腫を伴ったびまん性扁平黄色腫

・全身の85％に及ぶびまん性扁平黄色腫（diffuse plane xanthoma：DPX）を経験した．

・M蛋白血症として長期間経過した後に，多発性骨髄腫を発症した．

・M蛋白が指摘される前から皮疹は存在していた．

（「症例のポイント」より）

　

Diffuse plane xanthoma associated with multiple myeloma

　

Harada, Ken1）Kitamura, Hideo1） 1）Department of Dermatology, Aomori Prefectural Central Hospital

　

A 64-year-old male with multiple myeloma developed diffuse plane xanthoma (DPX) on his trunk and extremities;while the hands and feet and periorbital region were spared, about 85% of the entire body surface was affected. In Japan, DPX is rare, however, a significant association with hematological disorders has been observed. Most Japanese cases with DPX have monoclonal gammopathy of undetermined significance (MGUS). MGUS is associated with a high risk of multiple myeloma. It is important to consult a hematologist in patients diagnosed as having DPX.