シロリムス外用薬が有効であった結節性硬化症に伴う葉状白斑と血管線維腫

・葉状白斑（3カ月，女）と血管線維腫（14歳，女）を呈する結節性硬化症2例にシロリムス外用薬を用いた．

・結節性硬化症の異なる皮疹に対して，いずれもシロリムス外用が有効であった．

（「症例のポイント」より）

　

Hypopigmented macules and angiofibromas accompanied by tuberous sclerosis were successfully treated by topical sirolimus

　

Kinoshita, Manao1）Oshima, Naoya2）Shimada, Shinji3）Kawamura, Tatsuyoshi1） 1）Department of Dermatology, University of Yamanashi 2）Department of Plastic Surgery, University of Yamanashi 3）University of Yamanashi

　

We treated two patients of tuberous sclerosis with skin lesions by topical sirolimus. A baby at 3 months old who had many hypopigmented macules on the trunk and limb was treated by topical sirolimus for 6 months, and their macules faded. A 14 years old woman who had many angiofibromas on the cheek was also treated by topical sirolimus for 5 weeks, and their angiofiromas also remitted. Topical sirolimus might have a potential to treat for many types of skin lesions in tuberous sclerosis.