急激な経過をたどった，CD56陽性・ALK陰性全身型未分化大細胞リンパ腫

・臀部潰瘍を契機に診断された全身型未分化大細胞リンパ腫（anaplastic large cell lymphoma：ALCL）を経験した． ・ALK陰性かつCD56陽性であり，極めて悪性度が高く，急速な転帰をとった． （「症例のポイント」より）

A case of CD56-positive ALK-negative anaplastic large cell lymphoma with rapid progression to death

Takashima, Yuka1）Moriuchi, Reine1）Hotta, Moeko1）Yamaguchi, Keisuke2）Yamamoto, Satoshi2）Shimizu, Satoko1） 1）Department of Dermatology, Sapporo City General Hospital 2）Department of Hematology, Sapporo City General Hospital

Abstract A 65-year-old female was referred to our hospital with ulcers on the right buttock. A skin biopsy specimen from the buttock showed infiltrates of massive large atypical cells that were positive for CD3, CD4, CD30, CD56 and negative for ALK. A PET-CT scan showed multiple FDG uptake throughout the body. We made the diagnosis of ALK-negative systemic ALCL, which is known to have a very poor prognosis. The patient died 45 days after the first visit. CD56 positivity is known to be an indicator of poor prognosis in ALCL. As seen in previous studies, our case had a rapidly progressive course.