Volume 25, Issue 7 (June 2015)

Bone and Nutrition. The vitamin D functions in osteoblasts and osteocytes. Sawatsubashi Shun 1 1Department of Nuclear Receptor Ligands and Vitamins Research, Fujii Memorial Institute of Medical Sciences, Tokushima University, Japan. pp.991-997
Published Date 2015/6/28
DOI https://doi.org/10.20837/4201507043
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 The active form of vitamin D, 1α,25-dihydroxyvitamin D3(1α,25(OH)2D3), plays a key role in mineral and bone homeostasis. 1α,25(OH)2D3, through binding to the vitamin D receptor(VDR), a member of the nuclear receptor superfamily, regulates the expression of many genes in osteoblasts and osteocytes. The VDR functions in a largely 1α,25(OH)2D3-controlled manner by interacting directly with vitamin D response elements located within regulatory regions that are linked to cell-specific target genes. However, the mechanism of VDR action on these bone cell types remains largely unknown. While the direct actions of 1α,25(OH)2D3 on bone cells are complex and include both cell autonomous and paracrine mechanisms. In this review, we discuss how the VDR affects the transcriptional response of these cells and contribute to bone homeostasis.


25巻7号 (2015年6月)
電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社