Update on recent progress in vitamin D research. Vitamin D and bone, mineral metabolism. Masuyama Ritsuko 1 1Department of Molecular Bone Biology, Graduate School of Biomedical Sciences, Nagasaki University, Japan. pp.1525-1532
Published Date 2017/10/28
DOI https://doi.org/10.20837/4201711017
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 Vitamin D endocrine system is required for bone and mineral homeostasis through the active form of vitamin D[1α,25(OH)2D3]transported to the target organs, where the vitamin D receptor(VDR)is present. The biological significance of 1α,25(OH)2D3-VDR signalling is regarded not only in classical target of vitamin D involved in calcium and phosphate homeostasis, such as intestine, bone, kidney and parathyroid glands, but also in many other non-classical target cells of vitamin D including skin keratinocytes, pancreatic β cells, cardiomyocytes, T-lymphocytes, bone marrow macrophages, among others. Although 1α,25(OH)2D3-VDR signalling in classical target organs of vitamin D has been extensively studied, its precise function in these target organs still needs further investigation.


電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社