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Japanese

Improving effects of the food containing dried powder of unripe Citrus unshiu fruits on nasal symptoms in the subjects with perennial nasal hypersensitivity Megumi Futamura-Masuda 1 , Yumiko Tokunaga 1 , Takahiro Deguchi 1 , Takeshi Zentani 1 , Tadao Enomoto 2 , Kazuya Murata 3 , Hideaki Matsuda 4 pp.986-996
Published Date 2016/6/15
DOI https://doi.org/10.20837/3201607106
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 The objective of this study was to evaluate the effect of the food containing dried powder of unripe Citrus unshiu fruits(CUP)on nasal symptoms scores, blood test, and nasal mucosa test in subjects with perennial nasal hypersensitivity. A randomized, double-blind, placebo-controlled clinical trial was carried out. Thirty-nine subjects who had not been diagnosed as allergic rhinitis were randomized to CUP and placebo groups. Oral administration of tablets containing CUP for 8 weeks significantly improved nasal symptoms scores such as sneezing, nasal discharge, swelling and congestion and also improved eye watering score. On the other hand, placebo group showed no such improvements. In addition, there were no significant differences in blood test and nasal mucosa acidophilic leucocyte test between CUP and placebo groups. These results suggested that oral administration of the food containing CUP can alleviate the symptom of subjects with perennial nasal hypersensitivity.



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電子版ISSN 印刷版ISSN 1344-6932 医薬ジャーナル社

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