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Insights into Medications for Nephrotoxicity in the Perioperative Period Kenji NAKATA 1 , Yuri TANAKA 1 , Nobuhiko JOKI 1 1Department of Nephrology, Toho University Ohashi Medical Center Keyword: perioperative , AKI , CKD , drug induced kidney injury pp.607-614
Published Date 2024/9/10
DOI https://doi.org/10.18916/masui.2024090006
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 Drug-induced kidney injury(DKI)is defined as a new onset of kidney damage or a further deterioration of existing kidney damage due to a drug’s administration. With the ever-increasing aging of Japanese society, there are increasing concerns regarding elderly populations(e. g., the development of atherosclerosis, the management of chronic pain, and the development of malignant tumors)for whom drugs such as antihypertensive medications and contrast media are used when imaging and treatment are undertaken. The elderly are more prone to acute kidney injury(AKI), which can progress to chronic kidney disease(CKD). It is estimated that approx. 13.3 million people in Japan(approx. one in eight adults)have CKD, which is a risk factor for the development of AKI. It appears that the risk of developing or exacerbating AKI/CKD increases with age since the frequency of exposure to the aforementioned agents increases with advancing age. Angiotensin-converting enzyme inhibitors(ACEis)and angiotensin receptor blockers(ARBs)are used for reno-protection, cardio-protection, and the treatment of hypertension, and non-steroidal anti-inflammatory drugs(NSAIDs)are used for inflammation and pain management. The use of contrast media for thorough examinations of organs must address the evidence the above-mentioned drugs and contrast media can cause renal damage. Precautions regarding the use of these drugs and contrast media are discussed in this article, as are the mechanisms that underlie renal damage.


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電子版ISSN 印刷版ISSN 0021-4892 克誠堂出版

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