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Nausea and Vomiting in Palliative Care Patients Natsuko NOZAKI-TAGUCHI 1 1Department of Anesthesiology, Graduate School of Medicine, Chiba University Keyword: chemotherapy induced nausea and vomiting , palliative care , serotonin , substance P pp.45-50
Published Date 2024/1/10
DOI https://doi.org/10.18916/masui.2024010010
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 Cancer patients experience nausea and vomiting due to the disease itself, from treatments such as chemotherapy or radiation, and from other complications that patients may have. The most frequent and severe symptoms usually occur during chemotherapy, and thus the most thoroughly studied mechanisms and treatment options are those for chemotherapy-induced nausea and vomiting(CINV). Serotonin and substance P are key neurotransmitters. After antagonists for serotonin and substance P were developed, patients’ nausea & vomiting could be successfully treated, thus enabling out-patient chemotherapy treatment. Knowledge gained in studies of CINV has spread to other areas such as opioid-induced nausea and vomiting, and some successful results have been reported. Olanzapine, the multi-receptor antagonist available as a major antipsychotic agent, has recently become widely used for late CINV treatment and for ameliorating appetite loss. Although there is a wide range of treatment options for nausea and vomiting, it is apparent that the nausea and vomiting that some patients experience during the terminal phase of disease(including cancer, renal failure, heart failure and others)may not respond to any of the available treatments, and continuous sedation may become the only choice for symptom relief. Further research toward the goal of safely achieving the relief of nausea and vomiting is thus necessary.


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電子版ISSN 印刷版ISSN 0021-4892 克誠堂出版

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