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The Effects of Sarpogrelate (5-HT2antagonist) on Coronary Artery Flow Velocity Dynamics Kazuhiro Ashida 1 , Kimio Satomura 1 , Bonpei Takase 1 , Takanori Tahara 1 , Tadashi Yamagishi 1 , Kouji Miyazaki 1 , Kou Arakawa 1 , Toshio Shibuya 1 , Akira Kurita 2 , Fumitaka Ohsuzu 1 1The First Department of Internal Medicine, National Defence Medical College 2The Medical Research Center, National Defence Medical College Keyword: セロトニン , ドプラガイドワイヤー , 冠微小循環 , serotonin , doppler guide wire , coronary microcirculation pp.619-623
Published Date 2000/6/15
DOI https://doi.org/10.11477/mf.1404902111
  • Abstract
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We examined the rapid cardiovascular effects of sar-pogrelate (5-HT2 antagonist) in 8 patients (4 male;average age 61 years) with ischemic heart disease whohad no significant coronary stenosis in the left anteriordescending artery (LAD). A dopplar guide wire waspositioned in the proximal portion of LAD, and isosor-bide dinitrate was administered intracoronarily. Thenwe measured the average peak velocity (APV) at restand peak hyperemic responses to intracoronary 30μgadenosine triphosphate (ATP). Coronary flow reserve(CFR) was calculated as the ratio of ATP-inducedhyperemic to baseline APV. In addition, we measuredblood pressure, heart rate and hemodynamic data(pulmonary arterial pressure, pulmonary capillarywedge pressure, cardiac output) using a Swan-Gantzcatheter. We repeated the measurements one hour aftera 200mg orally-administered sarpogrelate. Sarpogrelatedid not significantly change CFR, general hemodynamicdata or the diameter of LAD in coronary angiography,but increased APV at rest from 17.5±9.1 to 19.1±9.5cm/sec (p=0.03) and, at peak, hyperemic responses tointracoronary ATP were increased from 54.6±23.2 to64.1±30.9cm/sec (p=0.02). These findings indicate thata serotonin blocker, sarpogrelate, augments coronaryartery flow by coronary microcovasodilation.


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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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