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Diagnosis of hereditary tumors Kiwamu Akagi 1 1Department of Molecular Diagnosis & Cancer Prevention Saitama Cancer Center Keyword: 遺伝性腫瘍 , 放射線感受性 , 二次がん pp.189-194
Published Date 2020/3/10
DOI https://doi.org/10.18888/rp.0000001164
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Genetic testing has been conducted on an individual who is suspected hereditary cancer from personal history and family history. However, resent advances of genetic analysis changed situation drastically. The multi-gene panel testing such as OncoGuide and Foundation One has been conducted to explore the appropriate cancer therapy for advanced cancer patient, meanwhile unexpected genetic disease is sometimes found as incidental findings. About 8% of all cancer patients have a pathogenic variant in cancer predisposition gene. These patients and their relatives should be conducted regular medical check to detect cancer as early as possible. Although, some hereditary cancer such as Li-Fraumeni syndrome shows sensitive to radiation and radiation exposure increases cancer development. Therefore, health care worker must consider minimization of radiation exposure for these individuals.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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