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Peptide receptor radionuclide therapy:a prologue of the way to the future of Radio-Theranostics Shoko Takano 1 1Department of Radiation Oncology Yokohama City University Graduate School of Medicine Keyword: 核医学治療 , peptide receptor radionuclide therapy(PRRT) , prostate spesific membrance antigen(PSMA) pp.1513-1520
Published Date 2019/12/10
DOI https://doi.org/10.18888/rp.0000001086
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Peptide receptor radionuclide therapy(PRRT)is a type of molecular-targeted internal radiation therapy that involves the use of a small peptide ligand coupled with a chelated beta-emitter, and it is regarded as a breakthrough of theranostics in nuclear medicine. The use of chelators allows not only visualization of the drug bio-distribution before therapy, but also adaptive synthesis, and small ligands allow drastic reduction of radiation exposure for normal tissues with rich blood flow because of its quick accumulation for tumors. This approach has already been applied to PSMA theranostics and is expected to apply other molecules rapidly. In this article, I will introduce the evidence from other countries and mention the domestic situation regarding PRRT.


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電子版ISSN 印刷版ISSN 0009-9252 金原出版

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