抗ARS抗体症候群に関連した間質性肺炎のHRCT所見

HRCT features of interstitial lung disease patinets with antisynthetase syndrome

抗ARS（aminoacyl-tRNA synthetase：ARS）抗体は，アミノアシルtRNA合成酵素に対する自己抗体である。多発性筋炎/皮膚筋炎（polymyositis/dermatomyositis：PM/DM）に特異的な抗体とされ，最も高頻度（25～40％）に検出される自己抗体である^1）。同酵素に対する抗体陽性例は，筋炎，間質性肺炎，炎症性関節炎やレイノー現象などの症状との関連が強く，抗ARS抗体症候群と呼ばれている。特に陽性例の90％近くで間質性肺炎が認められ，関連が強いとされている^2）3）。

We evaluated the initial HRCT about the distribution and characteristics of interstitial lung disease in anti-ARS antibody group（14men, 20women）and PM/DM group（13men, 30women）.

In both groups, the majority of the patients have bilateral, lower and dorsal predominant distribution although diffuse distribution is more frequently seen in PM/DM group. Consolidation, traction bronchiectasis, volume loss, affinity to bronchovascular bundles, and no honeycombing are frequently seen in both groups. Interstitial lung disease seen on both antisynthetase syndrome and PM/DM have no obvious differences.