抗癌薬とnivolumab投与で長期生存が得られている肺多形癌術後再発の1例

Pulmonary Pleomorphic Carcinoma Relapsed after Surgery Surviving Long-term by Chemotherapy and Nivolumab

肺多形癌はまれな腫瘍で予後不良と報告され1），標準的治療も確立されていない．われわれは，術後再発した肺多形癌に対しdocetaxel（DTX）を含む抗癌薬投与とnivolumab投与で長期生存が得られている症例を経験したので，文献的考察を加え報告する．

A 60’-year-old man was referred to our hospital because of nodular shadow found at mass screening. We diagnosed the tumor as non-small cell lung cancer by transbronchial biopsy. Chest computed tomo-graphy showed a tumor shadow of 3 cm in diameter with cavity. Right middle lobectomy was performed and the pathological diagnosis was pleomorphic carcinoma of the lung. The tumor recurrence was found at 10 months after surgery, and was treated with cisplatin, docetaxel plus bevacizumab for 6 cycles. A complete remission was achieved, but regrowth at 5 months after chemotherapy was noted. The patient was treated with nivolumab following carboplatin, gemcitabine plus bevacizumab 3 cycles. A good partial response is continuing 2 years and 5 months after confirming recurrence.