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要旨
本調査の目的はC型慢性肝炎患者のライフスタイルと肝機能の関連を知ることである．1992年にT病院にHCV抗体陽性で入院した患者107名を対象とし，郵送法による調査を行った．41名を分析対象とし，1992年（以後，92年）と1998年（以後，98年）の生活活動強度と栄養摂取，血液検査値を調査した．生活活動強度は軽い15名，中等度16名，やや重い10名であった．平均年齢は57.4±9.4歳，平均通院期間は11.7±4.7年であった．栄養摂取や自覚症状は活動強度別で有意差がなかった．41名中39名がinterferon（IFN）を受けており，12名が強力ミノファーゲン（強ミノ）治療を受けており，IFNまたは強ミノ治療が著効であった者を除く34名について解析した．やや重いの活動強度で血清ビリルビンが高く，92年の軽いとやや重いにp＜0.01，98年の軽いとやや重いにp＜0.05と有意差がみられた．軽い・中等度の活動強度において，AST変動のない者が92年に比し，98年に有意に増加した（p＜0.01）．これらから，C型慢性肝炎患者の生活指導の重要性が示唆された．
Abstract
The purpose of this study was to investigate the relation between the lifestyles, such as daily physical activity and dietary status, and liver functions in patients with hepatitis C. 107 patients with positive serum HCV who had been admitted in T hospital in 1992 were studied by mail. 41 patients were enrolled, and levels of daily physical activity, dietary status, and blood examination values of the subjects were investigated. As a result, there were 15 light level patients, 16 moderate level patients, 10 light heavy level patients in terms of daily physical activity. The average age of the subjects was 57.4±9.4 years old, and an average period of following up the subjects was 11.7±4.7 years. There were no significant differences between levels of daily physical activity on dietary status, symptoms, variation of ALT and AST 39 among 41 patients received interferon treatments and 12 patients received Stronger -Neo-Minophagen C, 34 patients except for those who had complete responses were included for analysis. Subjects were compared by levels of daily physical activity and, serum bilirubin values of the patients in light heavy were higher, there was significant difference between in moderate and light heavy of '92 (p＜0.01), light and light heavy of '98 (p＜0.05). These results suggested that the instruction for lifestyles of patients with chronic hepatitis C was important.
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