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Analysis of Specific Distribution of ECM Degraded-Product in Wound Surface of Pressure Ulcer Hisako Matsumoto 1 , Yumiko Oshima 2 , Masahiko Yoneda 3 1Department of Nursing, College of Life and Health Sciences, Chubu University 2Kanagawa University of Human Services 3Department of Nursing & Health, School of Nursing & Health, Aichi Prefectural University Keyword: 細胞外マトリックス , 褥瘡 , MM P3 , ECM , pressure ulcer , MMP 3 pp.13-23
Published Date 2009/9/16
  • Abstract
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Abstract

 The aim of this study was to investigate the relationship between the molecular structure of the extracellular matrix (ECM) and the wound surface of pressure ulcers. Protein samples of excreted tissue fluid attached to the gauze surface of gauze from eight patients were extracted and subjected to examine for the presence of ECM-related molecules by utilizing specific antibody and ELISA to measure the enzymatic level of MMP3. It was revealed that i) western blot profiles differed from one another depending on the surface condition of the pressure ulcer; ii) a distinct immuno-staining profile was observed even in samples isolated from the same pressure ulcer; and iii) the MMP3 expression level also differed among protein samples. These results suggest that the molecular construction of the ECM around the wound surface of a pressure ulcer might differ from patient to patient. Therefore, it is important that nurses consider the nursing intervention based on the surface condition of pressure ulcers. In addition, MMP3-involvement in pressure ulcers is also suggested this enzyme has been detected in protein samples from the wound surface of pressure ulcers.


Copyright © 2009, Japan Academy of Nursing Science. All rights reserved.

基本情報

電子版ISSN 2185-8888 印刷版ISSN 0287-5330 日本看護科学学会

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