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Effect of Compressive Stress on the Extracellular Matrix in Human Fibroblasts and Endothelial Cells:Relation to Body Pressure When Pressure Ulcers Develop Hisako Matsumoto 1 , Yumiko Oshima 2 , Masahiko Yoneda 3 1Department of Nursing, College of Life and Health Sciences, Chubu University 2Kanagawa University of Human Services 3Department of Nursing & Health, School of Nursing & Health, Aichi Prefectural University Keyword: 胞外マトリックス , 圧力 , 褥瘡 , ECM , compressive stress induced , pressure ulcer pp.3-12
Published Date 2009/9/16
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Abstract

 The aim of this study was to elucidate the effect of physical body pressure on the destruction of the extracellular matrix (ECM) leading to pressure ulcers. Materials used were human normal skin fibroblast and umbilical endothelial cells. Following cultivation of both fibroblasts and endothelial cells in the presence or absence of physical pressure (50 mmHg), the change in cell morphology and ECM, levels of the degradation enzyme of ECM, such as MMPs, and alteration of gene expression were examined. In fibroblasts, in addition to the morphological change, down-regulation of fibronectin, up-regulation of versican, collagen, MMP3, and ADAMTS4 were observed, however, no prominent alteration was detected in endothelial cell morphology under the experimental conditions used. Therefore, it is suggested that physical body pressure of around 50 mmHg could be critical for dispersion of body pressure. However, physical pressure might also affect over all tissue, resulting in alteration of the ECM structure. It was suggested that nursing intervention based on not only the physical pressure but also the total over all tissue structure should be investigated.


Copyright © 2009, Japan Academy of Nursing Science. All rights reserved.

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電子版ISSN 2185-8888 印刷版ISSN 0287-5330 日本看護科学学会

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