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The use of prophylactic antimicrobial agents for prevention Yuya KAWAMOTO 1 , Norimichi UENISHI 1 1Department of General Internal Medicine and Emergency Medicine Fujita Health University School of Medicine pp.97-111
Published Date 2023/1/1
DOI https://doi.org/10.11477/mf.3102201056
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The purpose of this review is to evaluate the prevention of infection, particularly in patients with “acute pancreatitis,” “status-post splenectomy,” and “post-aspiration”. Antimicrobial therapy for patients with acute pancreatitis to prevent infectious pancreatic necrosis is generally not recommended. Clinical studies that support this view exclude patients with circulatory failure or multiple organ failure, and the pros and cons of prophylactic antimicrobial therapy in these patients are still unclear. Prophylactic antimicrobial agents and vaccines are important in patients status-post splenectomy. Indications for and duration of administering prophylactic antimicrobial agents vary according to guidelines. The vaccination schedule varies according to age, previous vaccination history, and surgical procedure (emergency or elective surgery). Aspiration pneumonitis (chemical pneumonia caused by aspiration of gastric contents) generally does not require administration of antimicrobial agents, but in practice it is often difficult to distinguish it from aspiration pneumonia. To date, there are no high-quality studies on the efficacy of prophylactic antimicrobial agents after aspiration, especially in patients after severe aspiration, which often depends on the judgment of the treating clinician.


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電子版ISSN 2186-7852 印刷版ISSN 1883-4833 メディカル・サイエンス・インターナショナル

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