Pathophysiology of COVID-19 Yuki KOTANI 1 , Yoshiro HAYASHI 1 1Department of Intensive Care Medicine Kameda Medical Center pp.493-503
Published Date 2021/7/1
DOI https://doi.org/10.11477/mf.3102200888
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Coronavirus disease 2019 (COVID-19) has resulted in a worldwide pandemic, and the number of confirmed cases is still increasing. Understanding the pathophysiology of COVID-19 is essential to find effective interventions to decrease the risk of infection and mortality. COVID-19 has two pathophysiologic characteristics, cytokine storm and coagulation abnormalities. These pathophysiologic features make acute respiratory distress syndrome (ARDS) associated with COVID-19 different from classic ARDS. Due to differences in the ARDS phenotype, patients with COVID-19-associated ARDS can require a different approach to ventilatory management. This paper describes the findings of the pathophysiology of COVID-19 and summarizes the mechanism and evidence for treatment options that can be effective for COVID-19.

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