Severe infections from ESBL/AmpC producing organisms Kentaro IWATA 1 1Division of Infectious Diseases Kobe University Hospital pp.41-46
Published Date 2019/1/1
DOI https://doi.org/10.11477/mf.3102200596
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Extended spectrum beta-lactamase (ESBL) and AmpC are both beta-lactamases associated with multi-drug resistant Gram negative organisms. They are relatively common in healthcare settings in Japan. Carbapenems are known to be effective against both but development of resistance to carbapenems urged the development of carbapenem sparing strategies. This paper reviews the microbiological and clinical basics of ESBL/AmpC producing organisms, and discusses the conditions where non-carbapenem antimicrobials can be used appropriately.

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