High flow nasal cannula(HFNC) Jun OTO 1 1Emergency and Disaster Medicine Tokushima University Hospital pp.433-446
Published Date 2018/4/1
DOI https://doi.org/10.11477/mf.3102200517
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High flow nasal cannula (HFNC) is a novel method of oxygen administration, which can deliver a high flow heated and humidified mixture of oxygen and air. HFNC has several physiological advantages over conventional oxygen therapy:a decrease in anatomical dead space, an application of positive airway pressure with potential recruitment of alveoli, a decrease in airway resistance and work of breathing, an increase in fraction of inspired oxygen, and improved mucociliary clearance. Recently, several well-designed randomized controlled trials showed non-inferiority or superiority of HFNC over non-invasive ventilation on intubation rates and mortality in patients with acute hypoxemic respiratory failure, with diverse underlying etiologies, including pneumonia, immunodeficiency and postextubation respiratory failure. This review article summarizes the literature on the positive physiologic effects, mechanism of action, and clinical application of HFNC.

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