INTENSIVIST Volume 10, Issue 2 (April 2018)

Biology of hypoxia Kiichi HIROTA 1 1Department of Human Stress Response Science, Institute of Biomedical Science, Kansai Medical University pp.259-269
Published Date 2018/4/1
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Although Joseph Priestley, a British natural philosopher and scientist, first isolated molecular oxygen and studied its nature nearly 250 years ago, the details of the mechanisms of the body's coordinated response to hypoxia were not unveiled until just 25 years ago. Humans have evolved complex circulatory, respiratory, and erythroid systems to ensure that oxygen levels are precisely maintained, since an excess or deficiency may be toxic and result in the death of cells, tissue, or the organism. Traditionally, oxygen sensing was thought to be restricted to specialized organs, such as the carotid body, which depolarizes within milliseconds in response to hypoxemia. It is now well recognized that all nucleated cells in the body sense and respond to hypoxia by themselves. The key molecules for coordinated oxygen homeostasis are the family of hypoxia-inducible factors including HIF-1, HIF-2, and HIF-3, which are transcription regulators that respond to reduced levels of oxygen and bind to specific DNA sequences, thus controlling the expression of genes that mediate adaptive responses. In this review, I will describe the coordinated systems of the HIF family from the point of view of Critical Care Medicine.

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10巻2号 (2018年4月)
電子版ISSN 2186-7852 印刷版ISSN 1883-4833 メディカル・サイエンス・インターナショナル