Age effects on reference serum creatinine and serum cystatin C levels in Japanese children Osamu Uemura 1 1Department of Pediatric Nephrology, Aichi Children's Health and Medical Center Keyword: シスタチンC , クレアチニン , 小児 , 慢性腎臓病 , 腎機能評価 pp.476-482
Published Date 2012/5/15
DOI https://doi.org/10.11477/mf.1542103008
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The reference values of serum creatinine (s-Cr) and cystatin C (CysC) were determined by the Committee of Measures for Pediatric CKD between 2008 and 2009. The correlations between s-Cr and body length were evaluated in subjects aged 2~11 years. The regression equation that passed through the origin was estimated as reference s-Cr=body length(m)×0.30. We also determined the relationships between body length and s-Cr by polynomial regression analysis in males and females separately. We found that reference serum CysC concentration gradually decreased during the first year after birth, thereafter becoming constant. Mean serum CysC concentration was slightly higher in children aged 1 year than in children aged ≥2 years. We would like to show methods to diagnose the stages of pediatric CKD patients using reference values of s-Cr.

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