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Age-dependent changes of insulin-like growth factors and gonadal hormones Tsuyoshi Isojima 1 , Susumu Yokoya 2 1Department of Pediatrics, Graduate School of Medicine, University of Tokyo 2Department of Medical Subspecialities, National Center for Child Health and Development Keyword: インスリン様成長因子 , 成長ホルモン , 思春期 , エストラジオール , テストステロン pp.471-475
Published Date 2012/5/15
DOI https://doi.org/10.11477/mf.1542103007
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Age-dependent changes of IGF (insulin-like growth factor)-Ⅰ, IGF-Ⅱ, testosterone, and estradiol from infancy through adolescence were outlined. During childhood, serum IGF-Ⅰ levels rise gradually, with attainment of adult levels at the onset of sexual maturation. They rise dramatically during puberty and gradually decline again to the adulthood levels. On the other hand, IGF-Ⅱ levels remain relatively constant throughout childhood. Testosterone and estradiol levels are high in the neonatal period, then decline to undetectable levels throughout childhood. They rise during puberty and attain the adulthood levels. Both chronological age and pubertal stage should be considered when these laboratory data are evaluated.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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