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Inflammatory processes of diseases in childhood and laboratory parameters Shumpei Yokota 1 1Department of Pediatrics, Yokohama City University Hospital Keyword: マクロファージ活性化症候群 , 若年性特発性関節炎 , 炎症性サイトカイン , 血球貪食症候群 , 病態転換 pp.483-489
Published Date 2012/5/15
DOI https://doi.org/10.11477/mf.1542103009
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Most diseases in childhood are caused by inflammatory processes such as infectious diseases, allergic disorders, and rheumatic diseases, and the inflammation is derived from pro-inflammatory cytokines. Pro-inflammatory cytokines induce fevers, loss of appetite and sleep, and lead liver cells to produce CRP and serum amyloid A. Moreover, excessive amounts of pro-inflammatory cytokines activate endothelial cells resulting in a rupture, and then activate coagulation system. The continuity of excessive pro-inflammatory cytokines in peripheral blood is then related to the progression of disseminated intravascular coagulopathy and multiple oxgan failure which is the causes of "inflammatory death". At the bedside, intensive monitor of laboratory parameters will be helpful to make an appropriate decision of therapy in time, and to cease the progressive processes.


Copyright © 2012, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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