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Antiphospholipid syndrome Tatsuya Atsumi 1 1Department of Medicine Ⅱ, Hokkaido University Graduate School of Medicine Keyword: 抗カルジオリピン抗体 , β2-グリコプロテインI , ループスアンチコアグラント pp.1193-1199
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102802
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Antiphospholipid syndrome is an autoimmune disease in which recurrent vascular thrombosis and/or pregnancy morbidity is associated with persistently positive antiphospholipid antibodies (aPL). Evidence shows that the dominant antigenic targets for aPL in APS are phospholipid (PL)-binding plasma proteins such as 2glycoprotein I and prothrombin. In daily practice, aPL play a role as markers of APS. However, the determination of aPL is not easy due to their heterogeneity. It is recommended to test aPL as a combination of ELISAs and clotting assays.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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