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Adult onset Still's disease Kohei Nagasawa 1 1Center of Rheumatology, Sawara Hospital Keyword: 不明熱 , サイトカイン , フェリチン pp.1186-1192
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102801
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Adult onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown etiology, characterized by spiking fevers with an evanescent rash and arthritis. Being a rare disease, AOSD is now known as a disease of unknown origin, giving rise to fever. The etiology of AOSD is currently unknown. Although no autoantibodies are seen in patients with AOSD, proinflammatory cytokines produced by activated macrophages may play critical roles in the pathophysiology of AOSD. In general, intermediate or high-dose steroids can well control the disease. For patients intolerant of steroids, immunosuppressive agents such as methotrexate (MTX) or cyclosporine A are needed. In recent years, some biologics are also sometimes used, of which IL-6 blocking agent, tocilizumab seems to be the most promising.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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