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Complement in autoimmune diseases : its role in diseases and significance as a biomarker Hideharu Sekine 1 1Department of Immunology, Fukushima Medical University School of Medicine Keyword: 補体活性化経路 , 補体と疾患 , 補体検査法 pp.1127-1134
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102793
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The complement system consists of more than 30 soluble and cell-bound proteins including negative regulators, and protects the host against bacterial pathogens by activation of 3 types of complement pathways : classical, lectin and alternative pathways. On the other hand, over-activation of the complement system causes various inflammatory disorders in the host. Measurement of serum complement component levels is useful for diagnosis and understanding of disease activity in certain renal, hepatic, hematologic and autoimmune diseases. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by production of autoantibodies, formation of immune complexes as well as inflammation in targeting organs, including the kidneys, via activation of the classical pathway. As a result, serum levels of C1q, C4, C3 and CH50 in SLE patients are often decreased due to their consumption and inversely correlate with disease activity.


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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