Pharmacogenetic approach to the treatment of rheumatoid arthriits Atsuo Taniguchi 1 1Institute of Rheumatology Tokyo Women's Medical University Keyword: 関節リウマチ , 薬理遺伝学 , 抗リウマチ薬 pp.1158-1162
Published Date 2010/10/15
DOI https://doi.org/10.11477/mf.1542102413
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Rheumatoid arthritis (RA) is a chronic inflammatory disease. The inflammatory process of the joint destroys articular architecture and causes a significant disability. The efficacy of disease modifying anti-rheumatic drugs is widely accepted. However, the outcome of the treatment with these agents is known to vary among patients. the pharmacogenomic studies on methotrexate, sulfasalazine and tumor necrosis factor-ainhibitors have been reported. These investigations suggest that the pharmacogenomic approach is useful for the treatment of RA although there are points to be considered before the translation of the pharmacogenomic date into clinical practice.

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