β-lactamases in gram-negative bacteria Yoshikazu Ishii 1 1Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University School of Medicine Keyword: β-lactamase , gram-negative bacteria , drug resistance pp.473-480
Published Date 2010/5/15
DOI https://doi.org/10.11477/mf.1542102289
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β-lactamases are enzymes that hydrolyze the peptide bond in the β-lactam ring. They can be classified into 4 different molecular classes-A, B, C and D in the schema by Ambler et al. Class A and D β-lactamases have developed the ability to hydrolyze oxyiminocephalosporins and carbapenems. In this manuscript, I will try to explain the characteristics of important β-lactamases and methods to detect them.

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