インフルエンザワクチン接種後に発症した突発難聴2症例

Sudden Deafness after Influenza Vaccination: AReport of Two Cases

I．はじめに

　インフルエンザワクチンは広範な接種が行われているにもかかわらず副作用の報告は少なく，とくにHAワクチンに変更してからは安全なワクチンといわれている。しかし稀ながら神経系の副作用の報告は散見され，とくに米国で多発したGuillain-Barré症候群の例は有名である^1〜3）。最近われわれはインフルエンザワクチン接種後に生じた興味ある突発性難聴2症例を経験したので，若干の文献的考察も加え報告する。

　Two cases of sudden deafness occurred immediately after influenza vaccination were presented. The characteristic clinical features of both cases were as follows:

　1. The neurological disorders (tinnitus and dizziness) occurred 3 days after vaccination.

　2. Their audiograms showed no response to sound on admission.

　3. They developed dizziness at onset, and electronystagmograms revealed vestibular dysfunction.

　4. The improvement of hearing loss appeared at low tones.

　5. The virus titer of influenza A showed over 8.

　6. The cerebrospinal fluid studies were negative.

　From this study it was thought that accumulation of the similar cases are needed for further discussion.