頭頸部悪性腫瘍患者における細胞免疫学的検査法の比較検討

HYPERSENSITIVITY REACTION IN PATIENTS WITH CANCER OF HEAD AND NECK REGION

　I．はじめに

　悪性腫瘍患者の細胞性免疫能と臨床症状，および予後との関連についての研究報告は多い^1）〜6）。また最近，悪性腫瘍に対する免疫療法が導入されるにおよび，担癌生体の免疫能を的確に把握することは，治療効果をしる上でも，またその後の治療を推し進める上でも不可欠のこととなってきた。一方，細胞性免疫能の測定法には種々の方法が開発，報告されているが，同一個体における各検査法の問の相関関係についての報告は少ない。われわれ臨床医にとつては，検査手技が容易で患者の負担も軽く，しかも信頼度の高い検査法が望ましい。そこで以前，MIT，PPD，DNCBについて報告したが^7），今回これに，リンパ球のsubpopulationを加えて検討してみた。

　A comparative study of intradermal reaction of lymphoid cell subpopulation, PPD and DNCB, was made on patients affected with cancer of the head and neck region in comparison to those who were normal in health.

　1. The T-cell count among the normal individuals averaged 1243 to ±622, while among the cancerous patients, it ran 790±597. The B-cell averaged normal was 666±334 but, with theaffected, it amounted to 579±334. With PPD there was a marked difference of 85.6% against 63.5% among the non-affected and the affected. DNCB registered 100% against 43.5% with the non-affected in comparison the affected.

　2. Positive results with PPD and DNCB were obtained among the normal individual as being interrelated but, there seemed to be no relation between the T-cell and PPD and DNCB.