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Analysis of mild barbiturate-moderate hypothermia therapy on the authors' 152 cases Young-Su PARK 1,2 , Jun-ichiro ISHIKAWA 1 1Department of Neurosurgery, Maizuru Municipal Hospital Keyword: mild barbiturate-moderate hypothermia therapy , severe head injury , cerebrovascular disease , vasospasm , complication pp.529-535
Published Date 1997/6/10
DOI https://doi.org/10.11477/mf.1436901403
  • Abstract
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Mild barbiturate-moderate hypothermia therapy was established for severe head injury and cerebrovascular disease. This study was conducted on 152 patients from April 1984 through July 1995. In this study were in-cluded patients with Glagow Coma Scale score of less than 8 points but those with serious systemic complica-tions and elderly and infantile patients were excluded. Our protocol consisted of administration of thiamylal Na 1.25-2.5mg/kg/h and droperidol 20-40μg/kg/h (mild barbiturate) while maintaining a core tempmera-ture of 32-34℃ (moderate hypothermia). The clinical outcome was good (GR, MD) in 58 cases, poor (SD) in 24 cases and bad (PVS, D) in 70 cases. This therapy was found to be particularly effective for preventing ischemic neurological damage in the vasospasm stage following SAH and severe head injury in young pa-tients.

However, this therapy did not prevent pneumonia, cardiac failure, arrhythmia and hypopotassemia from occurring frequently. We conclude that this therapy is contraindicated in the elderly, i. e, those older than 65 years.


Copyright © 1997, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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