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Clinicopathological Features of Dysembryoplastic Neuroepithelial Tumor (DNT):Four cases report Kiyotaka HASHIZUME 1 , Tatsuya TANAKA 1 , Go DAITA 1 , Yukichi YONEMASU 1 , Masae MIYAMOTO 2 , Naoyuki MIYOKAWA 3 , Shuuji WAKAI 4 , Hiroshi FUKUSHIMA 5 1Department of Neurosurgery, Asahikawa Medical College 2Department of Pediatrics, Asahikawa Medical College 3Department of Clinical Pathology, Asahikawa Medical College 4Department of Pediatrics, Sapporo Medical College 5Department of Neuropsychiatry, Hirosaki University School of Medicine Keyword: Dysembryoplastic neuroepithelial tumor , Complex partial seizure , Pathology , Hippocampectomy pp.743-748
Published Date 1994/8/10
DOI https://doi.org/10.11477/mf.1436900887
  • Abstract
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We reported four cases of dysembryoplastic neuroepithelial tumor (DNT) with intractable complex partial seizures, and analyzed their clinical and patholo-gical features. The age of patients ranged from four to nineteen years old. Three were boys and one was a girl. The age of seizure onset ranged from eight months to five years. They did not have any neurological de-ficits. In all cases, CT scan revealed a low density mass in the temporal lobe. Two cases demonstrated calcifica-tions, and another two cysts. The mass demonstrated low signal intensity in T-1 weighted MR images with mild contrast enhancement by Gd-DTPA. Long-term video-EEG monitoring revealed the epileptogenic focus in the temporal lobe on the side of the mass lesion.Anterior temporal lobectomy with total removal of the tumor was carried out in all cases. Hippocampectomy was performed in three cases in which intraoperative electrocorticogram demonstrated spike discharges in the hippocampus. In the surgical specimens, the tumor consisted of increased astrocytes, oligodendrocytes, and some neurons. A cortical nodule appeared in one case, and cortical dysplasia appeared in two cases. It was dif-ficult to distinguish the tumor of case 3 from ganglio-glioma because of mild neuronal atypia. The tumor of case 4 demonstrated increased capillary vessels and was also difficult to differentiate from vascular anomalies. The pathological diagnosis of DNT was still difficult. Consequently, we speculated that DNT included some transitional types between congenital anomalies and ganglioglioma.


Copyright © 1994, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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